張召實驗室位於德克薩斯大學西南醫學中心（UT Southwestern Medical Center）的宿主防禦遺傳學中心（Center for the Genetics of Host Defense）。該中心由諾貝爾獎得主Bruce Beutler博士創立，並擁有全球最大的小鼠正向遺傳學誘變篩選平臺。實驗室的研究聚焦於代謝類疾病的分子機制，目標是將這些機制轉化為疾病治療策略。
實驗室已經篩選了超過一半的小鼠基因組，鑑定出數十種與肥胖、糖尿病、脂肪肝相關的新突變小鼠，並深入研究其分子機制。研究內容主要涉及功能未知的新基因及新型代謝表型，探索傳統代謝研究所未覆蓋的領域。自實驗室成立四年來，已在以下國際學術期刊上發表多篇研究論文，包括：PNAS（PMID: 32381739）、Nature Communications （PMID: 35842425）、Cell Metabolism（PMID: 36228616）、Trends in Cell Biology（PMID: 37336658）、The Journal of Clinical Investigation（PMID: 39137039）、Cell Death and Differentiation（PMID: 39562829）。實驗室的研究經費來源於美國國立衛生研究院（R00，R01，R21）和西南醫學中心。
目前，實驗室正在招聘博士後研究員，歡迎已獲得或即將獲得博士學位的同學加入我們的團隊。更多詳情請訪問實驗室網站（https://labs.utsouthwestern.edu/zhang-zhao-lab）或參閱以下英文招聘資訊。
Postdoctoral Position in Molecular Mechanisms of Metabolic Diseases
A postdoctoral training position is available in the laboratory of Dr. Zhao Zhang, in the Center for the Genetics of Host Defense at UT Southwestern Medical Center to study molecular mechanisms of metabolic diseases.
The Zhang laboratory combines a unique mouse forward genetic screening approach with biochemistry and molecular biology to identify new regulators of major metabolic diseases, including obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD).
Since the lab’s establishment in 2020, our work has led to publications in prestigious journals including PNAS, Nature Communications, Cell Metabolism, Trends in Cell Biology, The Journal of Clinical Investigation, and Cell Death and Differentiation.
Our laboratory has several exciting projects related to: 1) The dynamic regulation of a newly identified E3 ubiquitin ligase in insulin signaling. 2) The role of several new genes in the regulation of obesity. 3) The mechanism of several new genes in the pathogenesis of MASLD. The research in our laboratory is funded by CGHD and several NIH grants (R00, R01, R21).
Candidates must hold a recent Ph.D. and/or M.D. degree. Experience in cell signaling, mouse genetics, fatty liver disease, obesity, and diabetes research leading to publication in peer-reviewed journals is recommended.
Information on our postdoctoral training program, benefits, and a virtual tour can be found at http://www.utsouthwestern.edu/postdocs.
Interested individuals should send a CV, statement of interests, and a list of three references to:
Zhao Zhang, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8505
https://labs.utsouthwestern.edu/zhang-zhao-lab
https://profiles.utsouthwestern.edu/profile/155419/zhao-zhang.html